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A particular adverse effect results from interference with gonadal hormones, as evidenced by the development of gynecomastia (enlargement of male breast). Clinical uses include conditions of increased aldosterone secretion, e. g. , liver cirrhosis with ascites.
Interactions. Antacids inhibit iron absorption. Combination with ascorbic acid (Vitamin C), for protecting Fe2+ from oxidation to Fe3+, is theoretically sound, but practically is not needed. Parenteral administration of Fe3+ salts is indicated only when adequate oral replacement is not possible. There is a risk of overdosage with iron deposition in tissues (hemosiderosis). |
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