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Following its uptake into the body, the drug is distributed in the blood (1) and through it to the various tissues of the body. Distribution may be restricted to the extracellular space (plasma volume plus interstitial space) (2) or may also extend into the intracellular space (3).
Rapid control of an acute attack of mania may require the use of a neuroleptic (see below). Alternate treatments. Mood-stabilization and control of manic or hypomanic episodes in some subtypes of bipolar illness may also be achieved with the anticonvulsants valproate and carbamazepine, as well as with calcium channel blockers (e. g. , verapamil, nifedipine, nimodipine). |
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